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Fairness is not a satisfactory substitute for quality of service, if only because users have no means of verifying that they do indeed receive a ``fair share.'' Perceived throughput depends as much on the number of ows currently in progress as on the way bandwidth is shared between them. This number is not xed but varies randomly as new transfers begin and current transfers end. A reasonable starting point to evaluating the impact of random traf c is to consider an isolated link and to assume new ows arrive according to a Poisson process. On further assuming the closed-loop control achieves exact fair shares immediately as the number of ows changes, this system constitutes an M=G=1

factors affecting LD50 determinations, the advantages and disadvantages of requiring such tests, and the nature and value of the information derived. It concludes that the acute toxicity test (single-dose toxicity) is still of considerable importance for the assessment of risk posed by new chemical substances, and for a better control of natural and synthetic agents in the human environment. It is not permissible, however, to regard a routine determination of the LD50 in various animal species as a valid substitute for an acute toxicity study.

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pyrazofurin 6 showed activity in the CPE assay196 198 but not by using the virus yield reduction assay.196 Known inhibitors of IMPDH198 and SAH hydrolase196,198 were inactive. Other active compounds identi ed by screening include glycyrrhizin,197 niclosamide199 28, and valinomycin200 29. Ribavirin 1 was not active,196,198,201,202 although some might argue that it would work at high concentrations.203,204 However, in initial clinical studies, ribavirin offered no apparent bene ts.205 207 Representatives of approved antiviral drugs have also been selected and tested. In one report, except for some IFN preparations, all were shown to be inactive against the SARS-CoV in vitro, including HIV protease inhibitors.200,204 However, a team in Japan reported that nel navir was able to decrease the production of virions from Vero cells.208 A preliminary uncontrolled open clinical trial in Hong Kong suggested Kaletra (a coformulation

processor sharing queue for which a number of interesting results are known [16]. A related traf c model where a nite number of users retrieve a succession of documents is discussed by Heyman et al. [13]. Let the link capacity be c and its load (arrival rate mean size=c) be r. If r < 1, the number of transfers in progress Nt is geometrically distributed, PrfNt ng rn 1 r , and the average throughput of any ow is equal to c 1 r . These results are insensitive to the document size distribution. Note that the expected response time is nite for r < 1, even if the document size distribution is heavy tailed. This is in marked contrast with the case of a rst-come- rst-served M =G=1 queue, where a heavy-tailed service time distribution with in nite variance leads to in nite expected delay for any positive load. In other words, for the assumed self-similar traf c model, closed-loop control avoids the severe congestion problems associated with open-loop control. We conjecture that this observation also applies for a more realistic ow arrival process. If ows have weights ji as discussed above, the corresponding generalization of the above model is discriminatory processor sharing as considered, for example, by Fayolle et al. [9]. The performance of this queueing model is not insensitive to the document size distribution and the results in Fayolle et al. [9] apply only to distributions having nite variance. Let R p denote the expected time to transfer a document of size p. Figure 16.1 shows the normalized response time R p =p, as a function of p, for a two-class discriminatory processor sharing system with the following parameters: unit link capacity, c 1; both classes have a unit mean,

Current Status Recently attention has been focused on developing alternatives to the classical LD50 test to reduce the number of animals used or re ne procedures to make exposures less stressful to animals OECD adopted several alternative methods for determining acute oral toxicity: a limit test for materials with anticipated low toxicity, a xed dose procedure, an acute toxic class method, and an up-and-down procedure The xed-dose procedure and the acute toxic class method estimate the LD50 within a dose range for use in classi cation and labeling The up-and-down procedure generates point estimates and con dence intervals of the LD50 and therefore may be useful in a wider set of applications The xed-dose procedure (Guideline OECD 420) aims to identify the appropriate hazard class for new chemicals; it does not provide a point estimate of the LD50.

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